I found both of these examples in CMYK magazine.
The first is for a sports drink called Serum. I really like the idea of using a medical theme throughout the packaging. They even took so far as to shape the containers like IV bags. It's a very unique approach.

The second example is a series of books by Hitchcock that were designed to look like screenplays, complete with coffee stains and all. Again, I thought this was a unique way of packaging something that could of been done very traditional and boring.